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In effect, the changes in gaba and dopamine levels caused by baclofen reduced the positive reinforcement effects of heroin on brain processes.

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Baclon USP is a whit to-whit, odolss pactically odolss cystallin powd. It is slightly solubl in wat, vy slightly solubl in mthanol and insolubl in chlooom.

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baclofen should be used with caution in patients with renal impairment and should be administered to end stage renal failure patients only if the expected benefit outweighs the potential risk see section 4.

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